[Rosetta@Home] hitparade van 15 december

[SleutelMan]

Belofte maakt schuld, dus zoals gewoonlijk was ik het statsposten gisteren weer vergeten. Dan maar vandaag om zo het estafettestokje over te nemen en hopenlijk morgen weer aan iemand anders door te geven .

Eigenlijk had ik deze stats al om 5 uur kunnen posten aangezien ik toen al wakker was (komt door slaapritme doordeweeks ), maar gelukkig kon ik met een beetje moeite nog net 2 uur blijven liggen voordat ik met veel moeite mn bed uitkwam . De stats hadden afgelopen dagen ook wat problemen, maar ik denk dat de kerstdrukte, in tegenstelling tot bij TNT post, daar de oorzaak niet van is .

Dan over tot de stats . De top 3 blijft gelijk, daaronder is het 1 achtbaan met stijgers en dalers . Wat nog wel opvalt is de FvdD, Cosmic Cows flusht zich weer de top 30 in, een waardige score voor een team met ranking #17 overall . En Plato krijgt nog een mijlpaal (15K-variant) thuisbezorgt, dit kan door de kerstdrukte misschien ietsje langer duren dan normaal .

De team daily is nog wel meer dan de subteam-daily een circus. TeAm AnandTech is helaas zeker van de #1 of #2 de afgelopen tijd terwijl DPC ergens op plaatsje 2, 3 pf 4 hangt. Enig voordeel is wel dat we op AnandTech een redelijk grote voorsprong hebben zodat die (op het moment) niet echt een bedreiging vormen (laat staan iemand anders ). De inhaalstats zijn nog niet helemaal gefixed, maar ik heb wel een gevoel dat dat klopt .

All right, genoeg gekletst, hier zijn de
[Rosetta@Home] hitparade van 15 december 2006

Subteams Daily Top 30
pos		daily	user	total		procent
1.	()	14.208,10	[DPC] Team ColdFusion	3.362.835,12	(4)	19,0 %
2.	()	7.179,16	Cureseekers	6.620.193,80	(1)	9,6 %
3.	()	4.900,85	Mbc	963.109,51	(11)	6,5 %
4.	( 3)	3.424,24	Metal-Phantom	1.930.809,67	(8)	4,6 %
5.	( 1)	2.800,65	Los Alcoholicos	4.197.384,00	(3)	3,7 %
6.	( 1)	2.577,76	Grutte Pier [Wa Oars]	2.948.838,06	(5)	3,4 %
7.	( 1)	2.532,38	[DPC]FOKschaap	6.016.463,24	(2)	3,4 %
8.	( 3)	2.023,56	Lmax	378.576,57	(26)	2,7 %
9.	( 1)	1.959,82	Patman	706.764,42	(16)	2,6 %
10.	( 1)	1.713,32	[DPC]Happy Hour	323.499,84	(30)	2,3 %
11.	( 1)	1.552,15	Chris	314.655,26	(31)	2,1 %
12.	( 1)	1.520,73	Stonie -= BigBusy.net =-	311.460,07	(33)	2,0 %
13.	( 3)	1.433,69	Radiation_lan	337.253,02	(29)	1,9 %
14.	( 4)	1.280,02	ZgAg	7.350,54	(291)	1,7 %
15.	( 1)	951,79	DeeDee	38.277,86	(124)	1,3 %
16.	( 13)	887,63	Team_Gaol	1.182.498,94	(10)	1,2 %
17.	( 3)	862,41	Tukkertje	740.790,55	(15)	1,2 %
18.	( 3)	850,93	paraiko	247.143,45	(37)	1,1 %
19.	()	820,32	[DPC]Remmus	222.142,02	(43)	1,1 %
20.	()	734,20	Koen	32.326,23	(141)	1,0 %
21.	( 6)	732,78	TeamBVD	932.078,80	(12)	1,0 %
22.	( 2)	732,36	Da_Bink	379.141,74	(25)	1,0 %
23.	( 6)	606,46	Team_Bitstorm	236.316,15	(39)	0,8 %
24.	( 31)	603,53	Cosmic Cows	596.757,93	(17)	0,8 %
25.	( 5)	596,11	Team_Elteor_Borislavj	2.187.891,10	(6)	0,8 %
26.	( 1)	521,86	Creative ID	314.066,99	(32)	0,7 %
27.	( 33)	499,70	Jeroen v R.	24.469,90	(165)	0,7 %
28.	( 1)	459,49	Erik	73.602,99	(86)	0,6 %
29.	( 1)	423,60	Warpozio	81.105,04	(81)	0,6 %
30.	( 23)	422,37	Intact	22.435,01	(169)	0,6 %
More...

Subteams Overall Top 30
pos		overall	user	daily		procent
1.	()	6.620.193,80	Cureseekers	7.179,16	(2)	11,6 %
2.	()	6.016.463,24	[DPC]FOKschaap	2.532,38	(7)	10,5 %
3.	()	4.197.384,00	Los Alcoholicos	2.800,65	(5)	7,4 %
4.	()	3.362.835,12	[DPC] Team ColdFusion	14.208,10	(1)	5,9 %
5.	()	2.948.838,06	Grutte Pier [Wa Oars]	2.577,76	(6)	5,2 %
6.	()	2.187.891,10	Team_Elteor_Borislavj	596,11	(25)	3,8 %
7.	()	2.133.342,65	BurnHard	0,00	(577)	3,7 %
8.	()	1.930.809,67	Metal-Phantom	3.424,24	(4)	3,4 %
9.	()	1.303.971,24	[DPC]TeamHC	33,62	(129)	2,3 %
10.	()	1.182.498,94	Team_Gaol	887,63	(16)	2,1 %
11.	()	963.109,51	Mbc	4.900,85	(3)	1,7 %
12.	()	932.078,80	TeamBVD	732,78	(21)	1,6 %
13.	()	808.857,89	[DPC]Team Switch	20,05	(143)	1,4 %
14.	()	759.757,51	borkescomputers	62,73	(105)	1,3 %
15.	()	740.790,55	Tukkertje	862,41	(17)	1,3 %
16.	()	706.764,42	Patman	1.959,82	(9)	1,2 %
17.	()	596.757,93	Cosmic Cows	603,53	(24)	1,0 %
18.	()	572.070,37	NoizyCows	0,00	(412)	1,0 %
19.	()	550.700,00	[DPC]Division_Brabant	51,53	(111)	1,0 %
20.	()	537.490,82	Dutch Power Chicken	0,00	(379)	0,9 %
21.	()	492.956,99	DPC_Schotse_Hooglanders	35,58	(127)	0,9 %
22.	()	402.559,70	MolAnO	0,00	(476)	0,7 %
23.	()	398.650,14	M_P_G	0,00	(683)	0,7 %
24.	()	398.645,29	AJSL	184,97	(61)	0,7 %
25.	()	379.141,74	Da_Bink	732,36	(22)	0,7 %
26.	()	378.576,57	Lmax	2.023,56	(8)	0,7 %
27.	()	374.157,04	JZ-power	0,00	(384)	0,7 %
28.	()	359.109,94	Basjes	285,83	(42)	0,6 %
29.	()	337.253,02	Radiation_lan	1.433,69	(13)	0,6 %
30.	()	323.499,84	[DPC]Happy Hour	1.713,32	(10)	0,6 %
More...

Teams Daily Top 15
pos		daily	team	total		procent
1.	()	84.948,80	TeAm AnandTech	33.821.440,95	(4)	4,3 %
2.	( 1)	74.511,10	Dutch Power Cows	57.055.700,97	(3)	3,7 %
3.	( 1)	71.904,90	Czech National Team	13.468.033,14	(7)	3,6 %
4.	( 1)	60.146,60	Canada	16.458.239,47	(6)	3,0 %
5.	( 2)	56.146,60	Free-DC	57.167.810,48	(2)	2,8 %
6.	( 2)	48.967,40	University of Wisconsin - Madison	5.509.232,91	(20)	2,5 %
7.	( 2)	48.577,50	Baker Lab	2.835.092,84	(37)	2,4 %
8.	()	43.444,70	BOINC Synergy	11.104.771,66	(10)	2,2 %
9.	( 3)	42.286,50	TSC! Russia	4.552.643,51	(25)	2,1 %
10.	( 2)	32.461,00	Team MacNN	10.791.713,15	(11)	1,6 %
11.	( 1)	31.680,00	L'Alliance Francophone	8.569.581,92	(15)	1,6 %
12.	( 1)	30.860,10	Housing and Food Services	9.024.455,69	(13)	1,5 %
13.	( 2)	29.483,30	SETI.Germany	7.067.875,08	(16)	1,5 %
14.	()	27.703,20	Ars Technica	12.015.297,04	(8)	1,4 %
15.	( 2)	23.518,30	SETI.USA	10.348.308,15	(12)	1,2 %
More...

Teams Overall Top 15
pos		overall	team	daily		procent
1.	()	76.451.956,00	XtremeSystems	14.759,00	(29)	11,2 %
2.	()	57.167.810,48	Free-DC	56.146,60	(5)	8,4 %
3.	()	57.055.700,97	Dutch Power Cows	74.511,10	(2)	8,4 %
4.	()	33.821.440,95	TeAm AnandTech	84.948,80	(1)	5,0 %
5.	()	17.431.163,27	XPC	21.011,40	(19)	2,6 %
6.	()	16.458.239,47	Canada	60.146,60	(4)	2,4 %
7.	()	13.468.033,14	Czech National Team	71.904,90	(3)	2,0 %
8.	()	12.015.297,04	Ars Technica	27.703,20	(14)	1,8 %
9.	()	11.195.218,66	US-Distributed	19.110,20	(20)	1,6 %
10.	()	11.104.771,66	BOINC Synergy	43.444,70	(8)	1,6 %
11.	()	10.791.713,15	Team MacNN	32.461,00	(10)	1,6 %
12.	()	10.348.308,15	SETI.USA	23.518,30	(15)	1,5 %
13.	()	9.024.455,69	Housing and Food Services	30.860,10	(12)	1,3 %
14.	()	8.993.343,83	Phoenix Rising	16.735,50	(24)	1,3 %
15.	()	8.569.581,92	L'Alliance Francophone	31.680,00	(11)	1,3 %
More...

Mijlpalen
user	mijlpaal
Plato	15.000

When do we reach the 58.000.000?
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When do we get them...
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[trenza]

Het gaat goed met de estafette. Inmiddels al de dertiende estafetteposter.

De posters op een rij:
01 04-12-2006 Mobster
02 05-12-2006 archetta
03 06-12-2006 Bio1ogics
04 07-12-2006 cdkam
05 08-12-2006 squeez
06 09-12-2006 wwwhizz
07 10-12-2006 Kuuke
08 11-12-2006 FreezeXJ
09 12-12-2006 trenza
10 13-12-2006 C0w Crunch3rz
11 14-12-2006 Megaflix
12 15-12-2006 rblok
13 16-12-2006 SleutelMan

Wie gaat morgen voor veertien?

[Verwijderd]

Als ze er om 11 uur morgen nog staan doe ik ze.

[Kristof]

Vandaag krijg ik een hele lap tekst van David Baker onder mijn ogen geschoven. Ik neem aan dat iedereen van jullie dit ook even wil doornemen

Today I met with Nancy Hutchinson and her team of educators who work closely with teachers to design
and implement high school science units on proteins and molecular biology. Nancy's team and I are very excited to work jointly together to integrate rosetta@home into these units, and also to develop a "virtual" version of the course that would provide a comprehensive introduction to the science underlying proteins and rosetta@home which would not require a previous science background. Tim Herman, who produces beautiful models of proteins students can hold and manipulate will also be part of these efforts (see http://www.rpc.msoe.edu/cbm/). Nancy's program for teachers is described at
http://www.fhcrc.org/science/education/educators/sep/.

On the research front, the results from the last month of rosetta@home are really exciting. Chu Wang has made very dramatic progress in predicting the structures of protein-protein complexes: previously we were able to predict structures of complexes of two proteins given the structures of the two proteins
solved independently, but only when these structures do not change significantly when the two proteins interact. Now Chu, using the computer power you are so generously contributing, has been able to generate accurate predictions for complexes where the individual protein structures do change upon binding--he does this by simultaneously optimizing both the relative position of the two proteins and their structures; needless to say this is an extremely computationally demanding problem that would not be even thinkable without rosetta@home. This is an extremely important step forward since Chu's approach should now allow the prediction of protein-protein interactions quite generally, which is a very important problem in molecular biology.

Brian Kidd just showed me very promising results on another important problem: the modelling of protein conformational changes. Many proteins change their structure and function when they bind an activiating small molecule. Brian just started running his calculations on rosetta@home, and already has exciting results showing that, starting with the structure of proteins bind to such activators, if he removes the small molecule, the protein switches back to the state it is known to adopt experimentally in the absence of the small molecule. This is an step toward modeling the motions that underlie the signalling pathways used for communication within and between cells.

Finally, our continued analysis of the CASP7 rosetta@home predictions keeps getting more exciting--it turns out many of these blind predictions have an accuracy that is unprecedented, and that allows the models to be used for applications, such as solving the x ray crystallographic phase problem, that seemed out of reach earlier. The CASP7 assessor Randy Read made the first dramatic discovery with Rhiju and Bin's prediction, and he is continuing to work with us to better define the advances that have been made.

The next month or two we are going to start writing papers describing all of this progress which will highlight the contributions all of you have made, and we will also be continuing to attack new problems in the protein structure prediction and design area which you have made it possible to envision solving.
Also, as I've previously discussed, we will be beginning a concerted effort to bring full interactivity to rosetta@home, so you will be able to be involved in the research even more directly in the future!

[SleutelMan]

Verwijderd schreef op zaterdag 16 december 2006 @ 10:13:
Als ze er om 11 uur morgen nog staan doe ik ze.

Check, daar houd ik je aan . Aangezien ik morgen als enige dag van de week kan uitslapen (tot half 10 ) zal ik dat rond die tijd checken .