[World Community Grid] Nieuws updates

[Jis]

Vandaag is fase 2 van het project Discovering Dengue Drugs - Together van start gegaan. De tweede fase van het project is opgedeeld in 3 type units genaamd Type A, B en C. Type A dient als voeding voor B en B op zijn beurt dient als voeding voor C. Type C zal dan uiteindelijk worden opgestuurd naar de onderzoekers. Aanvankelijk zullen er dus voornamelijk Type A units beschikbaar zijn, maar geleidelijk aan zullen ze alle drie beschikbaar komen.

Eigenschappen van de type units:

Type	CPU tijd	Download	Upload	Code
A	30-100 uur	~20MB	~2MB	ps
B	5-10 uur	~2 of ~20MB	~2MB	se of pe
C	1-5 uur	~2 of ~20MB	< 1MB	sq,sd,sr of pq,pd,pr,pc,pl

Meer informatie over de units staat op het WCG Forum.

Meer informatie over het DDDT2 project is te vinden op de WCG Website.

[Jejking]

CPU-tijd 30-100 uur? Mama mia... op wat voor generatie processor op welke snelheid is dat gemeten of ingeschat?

[Roelant]

inderdaad zeg!

Overigens krijg ik nog geen werk voor het project aangeleverd?

[priens]

Bedankt voor de uitleg Jis! Het zijn inderdaad monster-units. Ik heb er een stel binnengehaald, deze zijn al 12 uur bezig (19,52% compleet) en hebben volgens BOINC nog zo'n 39 uur te gaan!

[edit] Het geheugengebruik is trouwens ook aanzienlijk. Continu iets boven de 200MB per workunit. Bij 8 units tegelijk wordt er dus al gauw 1,6GB van het geheugen opgeslokt!

[Voor 32% gewijzigd door priens op 18-02-2010 08:20]

[priens]

Goed om te zien dat de WCG projecten ook daadwerkelijk bruikbare resultaten opleveren. Dit las ik toevallig vanmorgen in het Technisch Weekblad

IBM in strijd tegen aids

11 maart 2010 Christian Jongeneel


Een netwerk van anderhalf miljoen computers in IBM’s World Community Grid heeft aanknopingspunten gevonden voor een nieuw medicijn tegen aids.

In een artikel in Chemical Biology and Drug Design van deze maand beschrijven onderzoekers van The Scripps Research Institute de vondst van twee nieuwe aanhechtingspunten aan enzymen die het aids-virus gebruikt om een cel binnen te dringen. De meeste aids-medicijnen werken door zich aan het enzym te hechten en het zo onklaar te maken.


Het World Community Grid bestaat uit pc’s, die in hun ‘vrije tijd’ aan wetenschappelijke klussen werken. Het is een van de eerste keren dat een dergelijk grid zulke direct bruikbare informatie oplevert.

Kijk, hier doen we het dus voor!!! Keep up the good work boys and girls!

[Jejking]

Dat was toch een paar weken geleden gepubliceerd op de wcg-site?

Ah ja dus: http://www.worldcommunity...sArticle.do?articleId=122

Goed werk inderdaad!

[priens]

Ah, oud nieuws dus... Bedankt voor de link!

Helaas heb ik tegenwoordig te weinig tijd om de WCG-site actief bij te houden, maar al bladerend in het Technisch Weekblad kwam ik dit toevallig tegen, vandaar...

[Jejking]

Daarnaast kwam ik dit tegen, toch wel leuk nieuws op het gebied van kankerbestrijding:

http://www.newscientist.c...OTC-rss&nsref=online-news

IMAGINE if cancer could be kept at bay by killing off precancerous cells every few months, much as dentists scrape away plaque to prevent tooth decay. Now drugs have been identified that do the job in mice.

[Voor 32% gewijzigd door Jejking op 02-04-2010 21:13]

[Jis]

In het projectoverzicht zag ik dat de volgorde van DDDT2 en Rice was veranderd. Het volgende bericht meldt dan ook dat Rice inmiddels is afgelopen.

All good things must come to an end and this is the case with the Nutritious Rice for the World project as the final results came in earlier this week.

We are analyzing the results and this will take some time. All of the scientists involved in this project are volunteers as well and we will be analyzing the data to identify proteins and genes that may be useful in breeding better rice strains. We are also applying for funding to further develop some of the technologies such as gpu acceleration of the process and sophisticated techniques that recognise structure and sequence patterns or signatures to identify the function of the protein.

There are some tentative plans to perhaps apply the software to other plant genomes.

More details are avaialble at http://protinfo.compbio.washington.edu/rice/status.html

On behalf of the scientific team involved I'd like to thank the IBM team for their support and enthusiasm for the project. Ensuring that the software could run properly on such a diverse set of hardware is quite an amazing feat and IBM deserves recognition for the time and resources that they have devoted.

However, none of this would have been possible without the help of the thousands of volunteers who donated their computers to this project. We consider it a great honour that you have allowed us onto their home machines to run our simulations these past years.

Thank you so much for your efforts.

Hong Hung

Over DDDT2 is te lezen dat het op Intermittent is gezet om duidelijk te maken dat er niet continue werk beschikbaar zal zijn.

[..]
So as an official post, we did change the project status from Active to now Intermittent in some places. The project is still considered Active Research.

The reason for changing it was to help members understand that there will be no work available from time to time. At this time, we do not see work being a steady in the terms of lots of work queued up waiting for members to receive it.

Thanks,
-Uplinger

[Jejking]

Aw crap, NRftW was nét het tweede project waar ik m'n Ruby badge mee wilde gaan verdienen

[Voor 16% gewijzigd door Jejking op 16-04-2010 10:46]

[wildhagen]

Rice was in principe al een paar weken geleden afgelopen, er was de laatste weken alleen nog wat openstaand reparatiewerk uitgegeven, meer niet.

Jammer, had net 337 dagen, hoopte daar het jaar mee te kunnen gaan halen. Rice Phase 2 dan maar afwachten?

[Jejking]

http://www.worldcommunity...sArticle.do?articleId=130

10 May 2010

Help Conquer Cancer project publishes paper

Category: Help Conquer Cancer
Tags: Publications and Presentations

Summary
The Help Conquer Cancer project researchers have developed an image-analysis and classification system for automatically scoring images from high-throughput protein crystallization trials.


Non-technical abstract:

The structure of cancer related proteins is important to know because their shape determines their function and role in the disease process. These proteins are usually large, so the only way to determine their structure is using x-ray crystallography. What makes this exceedingly time consuming is the necessary first step of getting the protein to crystallize. To do this, the scientists mix in varieties of compounds in the hope that this will help spur the crystallization of the protein. Using robots, many thousands of crystallization attempts are made. To determine if a crystal actually formed requires human observation and this is very time consuming.

By using World Community Grid, the scientists were able to developed an automated system for analyzing the images of the crystallization attempts and recognizing whether crystallization occurred. They have already trained the system to successfully recognize 80% of crystal-bearing images and eliminate 98% of clear drops. This significantly reduces the time required for human inspection, which should lead to much faster structure determination of proteins under study.

Eventually this should lead to a better understanding of the role of certain proteins in cancers and other diseases, which in turn should lead to identifying better treatments for these diseases.

Technical Abstract:

We have developed an image-analysis and classification system for automatically scoring images from high-throughput protein crystallization trials. Image analysis for this system is performed by the Help Conquer Cancer (HCC) project on the World Community Grid. HCC calculates 12,375 distinct image features on microbatch-under-oil images from the Hauptman-Woodward Medical Research Institute’s High-Throughput Screening Laboratory. Using HCC-computed image features and a massive training set of 165,351 hand-scored images, we have trained multiple Random Forest classifiers that accurately recognize multiple crystallization outcomes, including crystals, clear drops, precipitate, and others. The system successfully recognizes 80% of crystal-bearing images, 89% of precipitate images, and 98% of clear drops.

Journal that the paper appeared in: Journal of Structural and Functional Genomics.

For access to the paper, please click here.

[Jejking]

Valt ook wel redelijk in het WCG-straatje dus dank u Wildhagen, deze gaat even hier:

Scientists have devised a way to automate and accelerate a manual, complex process that enables researchers to more easily discover the structure of cancer-related proteins, and, eventually, formulate cancer cures. This new, automated approach may also help the exploration of other diseases and food-related research.

The breakthrough announced today was made by the Help Conquer Cancer project in conjunction with IBM (NYSE: IBM) and World Community Grid, a system of linked personal computers from volunteers who donate spare processing power for humanitarian projects. World Community Grid, sponsored by IBM, provides researchers around the world with the equivalent of millions of dollars of free computational power to enable medical, nutrition, energy and environmental research.

Tapping World Community Grid, the Help Conquer Cancer Project created a system that accurately recognizes when protein samples undergo a solidifying process called crystallization, which makes the proteins ready for further examination by special x-ray. The process is necessary for identifying, and eventually exploring, how the structure, shape and interaction of some proteins may have a role in causing cancer.

Using the Grid, scientists trained the system to successfully recognize 80% of crystal-bearing images and 98% of the clear drops of protein solution that existed prior to crystallization. This enables six times as many images per protein to be examined compared to human review, and in dramatically less time.

Automating the identification of crystals could speed research in numerous biological science and genetic research projects, as crystallization holds the key for investigating a variety of biological processes. It could also validate the efforts of other projects that seek to obtain protein structures, such as the Nutritious Rice for the World effort, which is also using the Grid to explore ways to create hardier, healthier strains of rice.

Meer info @ http://www-03.ibm.com/press/us/en/pressrelease/31902.wss

[Jejking]

The Clean Energy Project - Phase 2
• Please review the system requirements before opting to participate in this project

Ga je verder kijken... "only Linux x86 en x64 are supported"

What the fuck? Wat is dit nu weer voor discriminaliteit, kan iemand me uitleggen wat hier in vredesnaam het nut van kan zijn? Ik raak bijster not amused door dit soort mededelingen bij een dergelijk leuk project

Edit: heb nog even wat verder gezocht maar ik vind geen technische uitleg. Wél de mededeling dat TCEPP2 vanaf 17 juli ook voor Windows beschikbaar is. Zeg: kom maar op.

[Voor 17% gewijzigd door Jejking op 28-06-2010 19:59]

[Jis]

World AIDS Day event - FightAIDS@Home webcast replay

On World Aids Day, December 1, 2010, Dr. Alex Perryman provided a FightAIDS@Home project update via webcast. Here are the links to the webcast and the related Question and Answer session.

On World AIDS Day, December 1, 2010, Dr. Alex Perryman from The Scripps Research Institute conducted a live webcast, where he provided an update about the FightAIDS@Home project.

The Scripps Research Institute has been running the FightAIDS@Home project on World Community Grid since November of 2005, and Dr. Perryman provided an excellent update of their accomplishments.

The webcast was well attended but if you were unable to attend, you can view the presentation, as well as the related Question and Answer session, on YouTube.

FightAIDS@Home presentation given by Dr. Perryman:
[YouTube: http://www.youtube.com/watch?v=QfCj_4uoNDQ]

Question and Answer session:
[YouTube: http://www.youtube.com/watch?v=FlqZNBMPkVQ]

[Jis]

Er is weer een nieuw project gelanceerd:

World Community Grid - New Project: Drug Search for Leishmaniasis

We are pleased to inform you that World Community Grid has launched a new project called Drug Search for Leishmaniasis!

Leishmaniasis is one of the most neglected tropical diseases in the world. Each year this disease infects more than two million people in 97 countries. To date, there are no available vaccines to prevent the disease.

The researchers at the University of Antioquia in Medellin, Colombia, are running the Drug Search for Leishmaniasis project on World Community Grid to identify drug compounds that could possibly be developed into treatments for Leishmaniasis.

Please join us and donate your unused computer time to help search for a cure to one of the most neglected tropical diseases in the world.

For more information about this exciting project, please go to the Research overview on our website.

If you are currently contributing and want to check to see if you are contributing to this project, click here.

If you are no longer contributing but would like to contribute to this project, please click here.


Thank you,


The World Community Grid Team

[Witlof]

wat? Weer 1 Heb net goud binnen op DSFL

[Jis]

Witlof schreef op donderdag 08 september 2011 @ 22:30:
wat? Weer 1 Heb net goud binnen op DSFL

Witlof, Witlof... heb je nou alweer een valse start?

[Witlof]

Maar ik ben niet de enige hoor. Echt niet! Maar moet zeggen dat het nieuws via de mailing altijd wel redelijk vertraagd binnenkomt....

[Jis]

WCG heeft weer een nieuw project gelanceerd: GO Fight Against Malaria. We zagen vorige week al de beta's voorbij komen en de resultaten zijn nu dus goed bevonden.

Deze keer zal ik niet op het nieuwsbericht wachten, maar direct de overview plaatsen.

GO Fight Against Malaria

Project Status and Findings

Information about this project is provided on the web pages below. To comment or ask questions about this project, please submit a post in the GO Fight Against Malaria Forum.

Mission

The mission of the GO Fight Against Malaria project is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of malaria. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested and further developed into possible treatments for the disease.

Significance

Malaria is one of the three deadliest infectious diseases on earth and is caused by parasites that infect both humans and animals. Female mosquitoes spread the disease by biting infected hosts and passing the parasites to other hosts that they bite later. When these parasites replicate themselves in red blood cells (which the parasites use for food), the symptoms of malaria appear. Malaria initially causes fevers and headaches, and in severe cases it leads to comas or death. Plasmodium falciparum, the parasite that causes the deadliest form of malaria, kills more people than any other parasite on the planet. Over 3 billion people are at risk of being infected with malaria.

Although there are many approved drugs that are able to cure malarial infections, multi-drug-resistant mutant "superbugs" exist that are not eliminated by the current drugs. Because new mutant superbugs keep evolving and spreading throughout the world, discovering and developing new types of drugs that can cure infections by these multi-drug-resistant mutant strains of malaria is a significant global health priority.

Approach

Scientists at The Scripps Research Institute of La Jolla, California, U.S.A., will use IBM's World Community Grid to computationally evaluate millions of candidate compounds against different molecular drug targets from the malaria parasite. If these target molecules can be disabled, then patients infected with malaria can potentially be cured. The computations will estimate the ability of the candidate compounds to disable the particular target molecules needed by the malaria parasite to survive and multiply. Particular priority will be given to targets and candidate compounds which could attack the multi-drug-resistant mutant "superbug" strains of the malaria parasite. The power of World Community Grid can reduce to one (1) year what would take at least one hundred (100) years to complete using the resources normally available to the researchers at The Scripps Research Institute. The results computed on World Community Grid will be available in the public domain for all scientists to use and build upon in their research to develop drugs to fight malaria.

[Jis]

Vandaag zag ik opeens weer een nieuw project in de queue staan. Dit keer gaat het om onderzoek naar een wat minder bekende aandoening "Schistosomiasis" maar die toch jaarlijks de nodige slachtoffers maakt.

Uit Wikipedia:

Schistosomiasis (vroeger bilharzia) is een infectie met een van de parasitaire wormen Schistosoma mansoni, Schistosoma haematobium, of Schistosoma japonicum. Verder komen nog de minder bekende soorten S. intercalatum en S. mekongi voor. Deze vijf verwante soorten veroorzaken vergelijkbare, maar ietwat verschillende ziektebeelden. Wanneer de ziekte onbehandeld blijft, kan de infectie onder andere de longen, lever, milt, blaas en darm aantasten. Levensgevaar bestaat er meestal niet, maar de kwaliteit van leven kan in ernstige gevallen beduidend worden aangetast.

Hier een quote uit de overview pagina:

Say No to Schistosoma

Mission

The mission of the Say No to Schistosoma project is to identify potential drug candidates that could possibly be developed into treatments for schistosomiasis. The extensive computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins. This will help find the most promising compounds that may lead to effective treatments for the disease.

Significance

Schistosomiasis is a tropical disease caused by parasitic worms that are transmitted by freshwater snails. The disease kills 200,000 people each year and affects over 207 million people. Schistosomiasis is second only to malaria in its socioeconomic devastation. Researchers at the Infórium University in Belo Horizonte and FIOCRUZ-Minas, Brazil, are using World Community Grid to search for chemical compounds which may lead to new drugs for treating the disease.

Approach

A software program called VINA from The Scripps Research Institute in La Jolla, California, will be used to perform the virtual chemistry experiments. These virtual experiments will search to find which of millions of drug compounds might be able to disable particular proteins essential for the parasite's survival. Screening for the best potential drug compounds is an early step in the process of developing effective treatments for the disease. With enough computing power, this screening can be done much more quickly than using conventional laboratory experiments. Existing computers available to the researchers would require approximately 30 years to perform the screening. However, it is estimated that the power of World Community Grid can reduce the time required to one year or less. Information about the best candidate compounds will be published by the scientists, and this information will be available in the public domain for other scientists to build upon with their research. Further laboratory work using the best candidates identified by this project could lead to the development of better drugs to fight schistosomiasis.

[Jis]

En er is wederom een nouveau projectus aan de rij toegevoegd.

Voor wie de webcast wil volgen:
Dr. Gerard Learmonth, Sr. from the University of Virginia team will conduct a live webcast about this project on April 20, 2012 at 16:00 UTC. Please click here for more information about this webcast.

Project Overview:

Computing for Sustainable Water

Mission

The mission of the Computing for Sustainable Water project is to study the effects of human activity on a large watershed and gain deeper insights into what actions can lead to restoration, health and sustainability of this important water resource. The extensive computing power of World Community Grid will be used to perform millions of computer simulations to better understand the effects that result from a variety of human activity patterns in the Chesapeake Bay area. The researchers hope to be able to apply what is learned from this project across the globe to other regions which face challenges of sustainable water.

Significance

Water is the most abundant resource on Earth, yet the world faces many challenging water-related problems. Among them is the management of its freshwater resources. More than 1.2 billion people lack access to clean, safe water. This problem is becoming more critical in the world as the proportion of people living in dense urban environments rises. The resulting demands for water contend with increasing human activities which degrade the quality of available water. A complex set of interrelated forces makes the problem difficult to address, much less to solve effectively via coordinated policy.

Approach

The University of Virginia developed a participatory simulation model of the Chesapeake Bay, the UVa Bay Game® (www.virginia.edu/baygame), incorporating natural elements and human activity using game players representing crop farmers, land developers, watermen, and assorted regulators. The UVa Bay Game has been successful in providing a learning platform for conveying the issues of complex watershed behavior and management. But to better understand the complex natural and human dynamics at work in this complex system, a much more detailed simulation model was developed to run on World Community Grid. Each of many millions of computer simulations, using unique combinations of a wide variety of assumptions about the natural and human actions at play, will calculate the resulting effects on the watershed. Exploring these many results, the researchers expect to develop insight into how these assumptions affect the overall health of the Chesapeake Bay. With these insights, the researchers will be able to better inform policy makers and suggest how prudent actions can lead to water restoration and sustainability. The ultimate goal is to eventually apply this knowledge and the techniques learned with the Computing for Sustainable Water project to other watersheds around the world.

[Mist]

Bij gebrek aan recente hitparade hier maar een flinke schop om tussen het stampedegeweld even een paar nieuwtjes van afgelopen week te melden. Dit keer niet over nieuwe, maar over beëindigde projecten.

Belangrijkste is dat Discovering Dengue Drugs – Together phase 2 klaar is. Hiervoor waren ook al lange tijd geen taken meer op het Grid verspreid.

Discovering Dengue Drugs – Together, project update March 2013

Hello again to the members of World Community Grid. With this update, we announce that we are ready to call our projects completed. We thank World Community Grid, its member volunteers, and their computers for their help.

The major advanced from this project are as follows:

1) All calculations necessary to fully evaluate Phase 1 and Phase 2 of “Discovering Dengue Drugs – Together” have been completed. We are moving this project to a “completed” status and are assembling our results for posting on our web site. At this point, our calculations, which have used a combination of World Community Grid distributed computers and supercomputers from the Texas Advanced Computer Center (TACC; Austin, TX), have identified several new dengue protease inhibitors. These inhibitors have been validated in our laboratories using rigorous biochemical and cell culture assays. Most of these lead compounds inhibited both dengue and West Nile virus proteases. A handful of analogs developed from our initial computer-discovered dengue leads have entered crucial pre-clinical pharmacokinetic and efficacy studies. Thus, our World Community Grid project has been invaluable in helping identify dengue and West Nile protease inhibitors. We will be working over the next several years to turn these inhibitors into small molecules with properties suitable for human clinical trials.

2) Phase 2 of our project combined the computer resources of World Community Grid and TACC to provide unparalleled computing power to calculate the free energies of binding for several diverse proteins and a large number of potential ligands. We hypothesized that these extensive molecular dynamics calculations would provide statistical mechanical conformational ensembles from which we could accurately calculate free energies of binding. This was developed as a robust method to identify false-positive hits and more accurately discriminate between inhibitors and non-inhibitors. Unfortunately, calculations of the free energy of binding for a number of different protein:ligand systems did not match experimental measurements. Moreover, as we tested greater numbers of systems (facilitated by the combined computer resources of World Community Grid and TACC), we observed that an unacceptably large number of free energy calculations incorrectly predicted that known non-inhibitors would bind to a protein target. Thus, we conclude that the current state of free energy of binding calculations are not yet able to discriminate between binders and non-binders for every protein system However, as we reported earlier, there are some systems (e.g., lysozyme) where the free energy of binding calculations provided excellent discrimination between binders and non-binders. This work has shown that our current Phase 2 calculations are valuable at discriminating between true and false-positive hits for some target proteins, but not for all systems. We will continue our efforts to develop robust free energy of binding calculations that can be applied to a larger set of target proteins. This basic research project will not require the massive computing resources of World Community Grid at this time.

As always, we appreciate the time, effort, and dedication of World Community Grid members. The advances we are making in better understanding drug discovery software and its current limitations could not have been made without your efforts and your computer cycles.

Wisselende (voorlopige) successen bij dit project, hopelijk brengen de labtests meer vooruitgang.


De onderzoekers van het onlangs op de Grid beëindigde Help Cure Muscular Dystrophy - Phase 2 hebben ook een korte update over de post processing geplaatst:

The project is essentially completed. When we scanned all of the results, we still found a few incomplete work units that we are finishing up on our own cluster. These were problematic to run on the grid because they had extremely long run times (compared to a normal work unit). We will probably do one more double check to see if we missed anything in the process of filling in these results and then declare the project completed. The researchers will then be analyzing the data and eventually publishing their findings. We thank the members for all of their contributions to this project and World Community Grid in general.

Bij het Drug Search for Leishmaniasis project tot slot is nu zo'n tweederde van alle units verwerkt, dit project zal nog zeker een half jaar duren.

[Mist]

Help Conquer Cancer, WCG's enige project met GPU-ondersteuning, is bijna ten einde!

Niet al te opvallend is hierover vorige week een bericht op het forum geplaatst.

Based on current estimates, there is now approximately 25 days of new work remaining for the Help Conquer Cancer project. Once all new work has been sent out for the project, only resend work units will be available (work units not previously computed correctly or on time).

The launch of GPU processing has significantly accelerated the completion of this research and as a result, Help Conquer Cancer will complete over 2 1/2 years sooner than would be possible otherwise. We are also looking at our future projects to see if they could benefit from GPU processing as well.

Inmiddels zijn er nog ongeveer twee weken te gaan!

Twee interessante toevoegingen vanuit WCG verder in het topic:

To be honest, the combined production of the GPU's surprised us as well. We had anticipated that with the launch of GPU we would double the daily output. instead it increased by a factor of 16-17 (before GPU we were completing ~60k/results per day with 1 image per job, we are now >500k/results per day with 2 images per job. This led to some great adventures in handling greater capacity (which we call a 'success' problem).

The 'support' work load on the tech team is actually proportional to the number of active research projects we are running. As we reached 10-12 projects, the amount of time to complete 'moving forward' work dropped off significantly. As the projects end, we now have more time to focus on boarding new projects. We have a solid pipeline of new projects so there will definitely be more coming on board this year.

Dus voor iedereen die nog eens zijn GPU op WCG wil uitproberen of een HCC badge upgrade wil halen; de komende weken is je laatste kans!

Overigens denk ik dat het voor DPC vrij gunstig is, we hebben de GPU slag op dit project behoorlijk gemist en zijn de afgelopen maanden aan alle kanten ingehaald. Die misgelopen punten maken we niet zo snel meer goed, maar wellicht dat onze dagelijkse positie er weer wat florissanter uit gaat zien.

[Mist]

Het HCC onderzoeksteam heeft ook een update geplaatst: pdf.

Hierin bevestigen zij dat het project bijna voltooid is, gaan in op recente onderzoeksvoortgang en kondigen een nieuw WCG-project aan!

We are busy developing a new project that will search for prognostic and predictive signatures (sets of genes, proteins, microRNAs, etc.) that help predict patient survival and response to treatment.

[Suicyder]

Mist schreef op vrijdag 12 april 2013 @ 11:07:
Het HCC onderzoeksteam heeft ook een update geplaatst: pdf.

Hierin bevestigen zij dat het project bijna voltooid is, gaan in op recente onderzoeksvoortgang en kondigen een nieuw WCG-project aan!
[...]

Update hierop, laatste werk voor HCC is eruit en HCC is klaar.
http://www.worldcommunity...g/viewthread_thread,35068

Last of the new work for Help Conquer Cancer Sent

We have just finished distributing the last of the new work for the Help Conquer Cancer project. It will take about 7-10 days for the in progress work for the project to complete. During this time there will periodically be additional results sent out to finish up those in-progress workunits.

THANK YOU so much for your contribution and efforts on this project!

[Mist]

WCG heeft een algemene update gepubliceerd.

Summary
With centuries of donated computing time, volunteers have finished the computations for several popular research projects. Thank you! But there's still more work to do, as well as new projects and new features ahead!

Voor nu belangrijk:
Er is nog ongeveer 1 week werk voor Go Fight Against Malaria en zo'n 2 weken werk voor Human Proteome Folding- Phase 2.
Daarna zijn er tijdelijk slechts vier projecten actief. Wel zitten er nieuwe projecten in de pijplijn, in het bijzonder wordt in de zomer een opvolger van Help Conquer Cancer aangekondigd.

Overigens spijtig om te lezen dat sommige projecten om budgettaire redenen worden gestopt en niet zozeer omdat al het ooit beoogde werk is voltooid.

[Voor 9% gewijzigd door Mist op 29-05-2013 14:31]

[Jis]

Het is een tijdje rustig geweest met de projecten bij WCG, maar er is nu weer een nieuw project:

Mapping Cancer Markers

Het project bestaat uit het onderzoeken van 'markers' in DNA, RNA of proteïnen die voorkomen in gezond en kanker weefsel. Het betreft onder andere weefsel van long, eierstok, prostaat, alvleesklier en borst kanker.

Het doel van het project is drieledig:

• Identificeren van markers waarmee kanker vroegtijdig kan worden ontdekt.
• Identificeren van markers waarmee patiënten met een hoog risico kan worden ontdekt.
• Zoeken naar markers die de behandelbaarheid kunnen voorspellen op basis van een genetisch profiel van een patiënt.

In this project, researchers at the Princess Margaret Cancer Center in Toronto, Canada, are using World Community Grid to analyze a massive amount of data from tissue and blood samples of cancer patients and healthy controls to identify combinations of markers that play a role in the development, progression and treatment of various forms of cancers. Initially, the research will focus on lung and ovarian cancer, followed by prostate, pancreatic and breast cancers. The project is designed to accommodate additional cancers in the future.

Identifying all clinically useful markers would require thousands of patient samples and testing an astronomical number of marker combinations, which would be intractable even on World Community Grid. Instead, the researchers have developed software which uses heuristics (clever steps that reduce the enormous search space by focusing on the most relevant subsets of combinations) to greatly reduce the computational effort required to look for significant marker patterns. Even these software methods require a very large amount of computer processing power. By using World Community Grid, the researchers will use the Mapping Cancer Markers project to break down this overwhelming process into smaller, manageable tasks which can be performed by our volunteers' computing devices. World Community Grid therefore allows researchers to undertake this ambitious research.

Uitgebreide informatie over het project is te vinden op de project pagina's van World Community Grid.

[Jis]

Enige weken geleden is recruitment badges gelanceerd. Hiermee kan je badges verdienen door nieuwe vrijwilligers te vinden.

To celebrate a decade of scientific discovery, we're launching new badges to recognize volunteers for recruiting friends and family to World Community Grid. Start earning your badges today!

[Jis]

Vorige week is weer een nieuw project geïntroduceerd:

Uncovering Genome Mysteries

Dit project gaat onderzoek doen naar zo'n 200 miljoen genen waarvan het DNA al is uitgelezen, maar waarvan de functies nog niet bekend zijn. Door de computerkracht in te zetten van de vele vrijwilligers van World Community Grid wordt het mogelijk om deze DNA te classificeren en te vergelijken. Hierdoor wordt het dan veel eenvoudiger om de functionaliteit te ontdekken.

Because of recent advances in DNA sequencing technology, it is now possible to decode organisms' DNA very rapidly and identify their genes. However, the next step--understanding the function of each gene and the protein it encodes--is much more complex, making it very difficult to do so on a large scale.

Uncovering Genome Mysteries plans to change that by examining close to 200 million genes from a wide variety of life forms, such as microorganisms found on seaweeds from Australian coastlines and in the Amazon river. The predicted proteins they encode will be compared against each other to assess their similarity. When two proteins are similar, and the function of one protein is already known, this similarity allows scientists to make educated predictions about the function of the other.

The scale of the task is staggering. It is only feasible thanks to the massive computational power of World Community Grid. While sequences from all forms of life will be processed, microorganisms will receive a special focus.

[Witlof]

Yeah! Nieuw project, nieuwe badges

[Jis]

Het "Discovering Dengue Drugs - Together" (DDDT) project heeft geleid tot het vinden van een molecuul die bruikbaar kan zijn in het bestrijden van Dengue en varianten als West-Nile virus!

Op de WCG site is een artikel gepubliceerd waarin wordt gemeld dat dat er een doorbraak is geboekt door het DDDT project. Met behulp van het werk dat is gedaan door de vrijwilligers die DDDT hebben gedraaid is nu een molecuul ontdekt die o.a. het Dengue virus kan neutraliseren. Het molecuul heeft bovendien voor zover bekend geen negatieve bijwerkingen en is niet giftig. Er zal nog verder onderzoek verricht moeten worden, maar het is een goed resultaat!

Links:
WCG: Decade of Discovery: A new drug lead to combat dengue fever
NCBI: Identification of a Novel Inhibitor of Dengue Virus Protease through Use of a Virtual Screening Drug Discovery Web Portal

[Jis]

Er is alweer een nieuw project in WCG te vinden:

Outsmart Ebola Together

Het doel moge duidelijk zijn: Zoeken naar een middel om het Ebola virus te stoppen.

Outsmart Ebola Together is a collaboration between The Scripps Research Institute and IBM’s World Community Grid to screen millions of chemical compounds, searching for ones that can disable the Ebola virus.

My team at The Scripps Research Institute has already mapped nearly all of the critical proteins of the Ebola virus. These molecular images are like enemy reconnaissance: they show where the virus is vulnerable and can be targeted to block key stages of its life cycle.

Outsmart Ebola Together is a crowdsourced effort to dramatically accelerate our research. With the computing power donated by World Community Grid volunteers, we will be able to rapidly screen millions of chemical compounds to find the ones that can disable these crucial Ebola proteins - stopping the virus in its tracks.

Bron: https://secure.worldcommu...sArticle.do?articleId=401

[YouTube: http://www.youtube.com/watch?v=SrZ3x0Nxras]

[AtHomer]

Vanmorgen lukte het me niet om WU's voor het nieuwe ebola-project te krijgen, en daar is een reden voor:

Please note, this project is going to be running slower than our normal applications. So there will be periods during the day that no work can be downloaded for the application. So badge hunting in the early stages of this project will be difficult.

Thanks,
-Uplinger


Posted in the badge thread. In other words, it's a feature, not a bug.


Yes it is a feature right now, which is why we also made the project not auto opt-in. This way members who really want the work units download them instead of getting pulled by many other hosts.

The reason for it being slow is we have limited number of rigid work units available before we get to the flexible ones. As mentioned in the beta forums these flexible ones were taking a long time and without checkpoints. So we are working on a fix for that at the moment. Instead of getting to those flexible ones before the checkpointing is working better.

Please be patient as we ramp the project up to normal speed. As mentioned, in the early stages, badge hunting will be difficult. But we are planning to make it easier in the future.

As others have mentioned, we do have other great projects that you can donate your CPU time towards while the project is running slowly.

Thanks,
-Uplinger

Bron: http://www.worldcommunity...ad_thread,37507_offset,10

[furian88]

Ik wou net hier de vraag plaatsen waarom ik geen work toegestuurd kreeg hiervoor

Top!

[Jis]

FightAIDS@Home - Phase 2

Vandaag is deeltje 2 van het FAH project van start gegaan.

The team behind FightAIDS@Home is launching Phase 2 of the project, putting to use a more accurate simulation tool to help them determine which of the Phase 1 results merit further investigation. Phase 2 will also be applying this analysis technique at an unprecedented scale, which if proven successful, can benefit medical research not only for HIV but many other diseases as well.

Nieuwsartikel: Pioneering new techniques in the fight against HIV
Projectpagina: FightAIDS@Home - Phase 2

[Witlof]

Altijd leuk om weer nieuwe badges te kunnen halen

[Witlof]

Misschien leuk om weer eens een keer een battle te gaan doen of zo? Beetje actie hier bij DPC krijgen

Hello WCG-Community,

For Nov 16th to Nov 22th 2015 SETI.Germany is arranging a challenge at World Community Grid on the occasion of the grids 11th birthday:




We would like to invite every team to participate in the challenge and hope that your team and many members of your team will be joining and participting this party.

!!Be aware, only your WCG-Team-Captain can join your team to the challenge!!
So get in contact with your team captain!!!

How to join the birthday party:
http://www.worldcommunity...lenge.do?challengeId=7496

More information and statistics regarding the challenge can be found here:
http://www.seti-germany.de/wcg/1_en_Welcome.html
(site is under construction, so not everything is up to date!!)


Your participation is very much appreciated.

Bron: http://www.worldcommunity...g/viewthread_thread,38465

[Jis]

Wel leuk idee ja. Als we dan wat extra hulp krijgen kunnen we denk ik best ook wel een deuk in een pakkie boter slaan.

[Cow_tipping]

En wij als Brabanders hebben wel iets met een 11de verjaardag. (helaas niet de 11e van de 11e)

[Witlof]

Wie is dé DPC'ert die ons kan aanmelden

[Witlof]

Volgens mij zijn we nog niet aangemeld. Nu hebben we nog wel even, maar wie van de crew kan dit oppakken?

[KuuKe]

Moooh Koeien! Jullie zijn aangemeld voor de Challenge.

Check ur presence @ http://www.worldcommunity...lenge.do?challengeId=7496

Maak er een mooie battle van en ronsel maar genoeg koeien
Hmm, valt in een week dat ik verlof heb. Misschien maar eens quasi vergeten de computer uit te zetten

(heb een sql-database in notepad++ moeten doorspitten om de gegevens te vinden .....)

[Suicyder]

KuuKe schreef op woensdag 21 oktober 2015 @ 18:26:
Moooh Koeien! Jullie zijn aangemeld voor de Challenge.

Check ur presence @ http://www.worldcommunity...lenge.do?challengeId=7496

Maak er een mooie battle van en ronsel maar genoeg koeien
Hmm, valt in een week dat ik verlof heb. Misschien maar eens quasi vergeten de computer uit te zetten

(heb een sql-database in notepad++ moeten doorspitten om de gegevens te vinden .....)

danku O grote Ki...eh! Koe! voor de moeite van het spitten

[Witlof]

Yeah

[Cow_tipping]

Dus iedereen van DPC doet nu automagisch mee?

[Witlof]

Volgens mij heel DPC is nu als team ingeschreven voor deze challange.

Bedankt Kuuke

[KuuKe]

Jup, heel DPC doet volgens mij vanzelf mee. Een andere optie was er niet. Of we hadden een compleet nieuw DPC-team voor de challenge uit de grond moeten stampen.

Dit is volgens mij een stuk efficiënter

[Witlof]

Ach, winnen is belangrijker dan meedoen

[wildhagen]

Vandaag is er weer een nieuw project gestart bij WCG, het was uiteraard al een tijdje in een beta aan het lopen.

Het project heet 'Help Stop TB' (HST1), en zoals de naam al aangeeft gaat het zoeken naar medicijnen tegen tuberculose (TBC).

Nieuwsbericht: https://secure.worldcommu...sArticle.do?articleId=470

Projectpagina: https://secure.worldcommu...research/hst1/overview.do

[Witlof]

Nieuw project beschikbaar: http://www.worldcommunity...tent=body-content-article

We're excited to announce the first new project of 2016, Help Stop TB. Tuberculosis caused 1.5 million deaths in 2014, making it one of the world's deadliest diseases. But with help from volunteers like you, researchers can better understand this disease in order to overcome it.

[wildhagen]

Zojuist is het nieuwe project, OpenZika, live gegaan.

Zoals de naam al enigszins doet vermoeden gaat het hier om een project wat onerzoek gaat doen naar het Zika-virus.

Project pagina: https://secure.worldcommu...research/zika/overview.do

[Pyrus]

Gelijk daarop over gegaan! Hopen dat hier meer WU's beschikbaar zijn dan bij HST!

[Damic]

Pyrus schreef op woensdag 18 mei 2016 @ 19:12:
Gelijk daarop over gegaan! Hopen dat hier meer WU's beschikbaar zijn dan bij HST!

Is nog maar net open gegaan dus en als ik jou was zou ik meerdere projecten selecteren

[Pyrus]

Damic schreef op woensdag 18 mei 2016 @ 19:15:
[...]
Is nog maar net open gegaan dus en als ik jou was zou ik meerdere projecten selecteren

Ghe, ja... ach, optimisme kan geen kwaad. Eerste de beste nieuwe request voor werk heeft er gelijk een opgeleverd. Nu kijken of het ook zo blijft.

[Damic]

OpenZika duurt maar 15 minuten per WU voor mij en voor nog snellere systemen wrs nog sneller. ziet een taak van 52 minuten er tussen staan

[Voor 23% gewijzigd door Damic op 19-05-2016 08:13]

[Suicyder]

Even een kleine update:

Mapping Cancer Markers Begins Analyzing Lung and Ovarian Cancer Data - 17 Oct 2016 

OpenZika Researchers Choosing and Testing Potential Antivirals - 03 Nov 2016 

FightAIDS@Home Team Re-Opens Phase 1 - 1 Dec 2016

[Mist]

Pause for Smash Childhood Cancer project

As some of you have noticed, the current batch of work for the Smash Childhood cancer work will finish in about a week or so. We were expecting more work right away so that there would not be a pause. However, the researchers were not able to prepare the work for the next cancer targets as quickly as originally thought. Part of the difficulty has been obtaining exact structures of some of the targets. But, they expect to have another target to run soon. They are continuing to work on determining the structure of other targets and for even later, they are choosing additional targets for the future. So, please be patient and thank you for all of the contributions to date.

CEP phase 2, al enige tijd inactief, is overigens beëindigd een paar weken geleden:
Clean Energy Project Researchers Sharing Results and Planning for the Future

[Voor 13% gewijzigd door Mist op 14-04-2017 11:12]

[wildhagen]

Even een kick, want er zitten 3 nieuwe projecten aan te komen, allemaal klimaat-gerelateerd. Waarvan één Nederlands project, van de TU Delft.

De projecten:

- Impact of climate change on public health (Emory University, USA)
- Impact of atmospheric aerosols on climate change (Far Eastern Federal University, Russia)
- Rainfall modeling in Africa (Delft University of Technology, Netherlands)

Dit zijn de winnende 3 projecten, uit een totaal van meer dan 70 aanvragen. De projecten zouden in de komende maanden beschikbaar moeten komen via WCG.

Bron: https://www.worldcommunit...sArticle.do?articleId=558

[Jis]

FightAIDS@Home – Phase 1 researchers identified new potential targets for antivirals

https://www.worldcommunit...sArticle.do?articleId=629

By: The FightAIDS@Home research team
1 Jul 2020

Summary
A protein called HIV-1 capsid (CA), which is crucial to the replication of HIV, may have some recently discovered vulnerabilities.

Als ik het goed begrijp is er een 'gat' ontdekt in het virale RNA dat opgevuld kan worden waardoor het virus dan niet meer kan repliceren. Vervolgens is er met FightAIDS@Home – Phase 1 gezocht naar mogelijke kandidaten om dat gat te vullen en dat is dus blijkbaar gelukt.

Given these observations, we performed a preliminary high-throughput virtual
screen focusing on the NDI pocket using the FightAIDS@Home project (FA@H; http://
fightaidsathome.scripps.edu/Capsid/index.html) in collaboration with IBM’s World
Community Grid (https://www.worldcommunitygrid.org/). More than 1.6 million com-
mercially available compounds have been used to target, inter alia, 20 conformations
of the NDI pocket, selected from hexameric and pentameric interface assemblies.
Preliminary results show that the NDI pocket is a plausible binding site for antiviral
compounds (Fig. 9) from a molecular docking point of view. Evaluation and character-
ization of these compounds are the subjects of an ongoing independent study.

Fig. 9

In conclusion, through biochemical, virological, TEM, crystallographic, and MD
simulation analyses, we characterized interactions primarily present in pentameric
interfaces in the HIV-1 capsid core and showed them to be important for assembly. Our
data highlighted the importance of a novel N-terminal domain interface (NDI) pocket
that is amenable to antiviral targeting.

[Suicyder]

Synthetic Compound May Be Useful for Developing Zika Virus Treatment

[Suicyder]

Behind the Scenes with World Community Grid's Active Projects

Summary
Interested in learning more about our monthly calls with the researchers for each active World Community Grid project? You can get updates on our website, in our forum, and via email.

[Suicyder]

Delay voor het project weer de lucht in gaat komen van WCG.
The Home Stretch keeps Stretching… We need to delay restart until May 9th, 2022

[Tao]

Zo te lezen werken ze intern misschien ook met wat vrijwilligers (misconfiguratie VLAN etc.) ?

[wildhagen]

Mogelijk wéér verder uitstel voor herstart, vanavond definitief nieuws:

While we continue working hard to restart WCG as soon as possible, we want to provide an update on the current status. We are currently facing unexpected issues with the load balancer - a small but critical component that ensures science servers will cope with increased workloads. If we do not resolve this in time, it would prevent us from restarting on May 9th. We will provide an update on the result of our efforts to resolve the issue Sunday evening.

WCG downtime enabled teams to catch up with analyses and validations. ARP project continues to analyze data, and started to prepare the online portal to help disseminate the results to wider scientific community. OPN1 is busy validating results from the first round of computation (validation has been delayed due to problems in Europe). MCM is partially on pause until we fully restart (as the MCM team is now the WCG team). SCC is also finishing preclinical validation of previous drugs, and is preparing new targets for the computation on the WCG. We do have work-units prepared for the restart for both OPN1 and MCM projects.

We really appreciate all the support messages we have received on the last update, your patience and continued support of WCG and its projects.

Zie https://www.worldcommunitygrid.org/news/0507

Ik krijg nogal het idee dat dit een erg amateuristische organisatie is, als je hier pas na 2.5 (!) maand downtime achterkomt...

[m_p_g]

Voor een commerciële organisatie zou 2,5 maand downtime sowieso geen optie zijn.

We hebben hier echter te maken met een non-profit organisatie die heel andere prioriteiten zal stellen.
Wel vraag ik me af in hoeverre ze nog echte support van IBM krijgen voor een bepaalde periode...

[wildhagen]

En wederom verder uitstel:

Unfortunately, we must now conduct further testing starting tomorrow to confirm that the system is ready. While we were able to resolve issues with the load balancer HAProxy and partially address a second issue preventing clients from accessing certain queues published by our message broker internally, additional testing to confirm there will be no unexpected effects resulting from these changes is now needed due to security implications. We continue to work on this tonight and we aim to update you tomorrow [May 9th, 2022] with the revised start date for the WCG, unless we run into some unexpected challenges.

In preparation for the imminent restart of the WCG, the OPN project has prepared a substantial stockpile of packages on the OPN server for both OPN1 and OPNG. The newer packages are non-reactive and dock the ZINC library against PLPro, targeting the binding site of the ligand in PDB entry 7LOS.
This binding site was chosen because some of the molecules with activity in the lab experiments dock well to it. The OPN team plans to do reactive docking as well at some point on this same binding site.

(van hun facebookpagina, staat nog niet op de maintenance-website).

[wildhagen]

Verder uitstel, tot op zijn vroegst morgenavond (Canadese tijd, dus vrijdagochtend hier):

We performed further investigations into issues we have been experiencing with our message broker and IBM WebSphere. We were able to address the stale JAAS configuration in IBM WebSphere causing the issue whereby JMS connections that required updated credentials were not re-initialized so long as any credential of the correct alias already existed in the WebSphere config. Hence, the outdated credential simply survived scripted reconfiguration of WebSphere to pollute all queue and topic connections anew on restart. While our team used the typical diagnostic tools for IBM MQ we gleaned no additional insight from them and were significantly delayed in discovering the bug in our deployment scripting. Stepping through all configuration scripting and checking each referenced object manually in the WAS command line console revealed the issue only this morning.

As we are now able to continue with testing the system we plan to reassess the earliest WCG restart date we can commit to by Thursday evening (May 12th, 2022). We will post an updated schedule to social media and to the website on the 12th.

Aldus https://www.worldcommunitygrid.org/news/0510

[wildhagen]

En wéér verder uitstel, tot 24 mei:

The revised date for launch will be May 24th, 2022, after Victoria day.

We were able to solve a redirection loop that caused much of the website to be unusable due to incorrect rewrite rules in Apache and their interaction with self-hosted DNS. Additional issues were then resolved that had resulted from the previously discussed necessary changes to the configuration of HAProxy, internal server certificates and thus domains, and IBM WebSphere.

We are now updating the content on the production website to include the updates that were published during downtime, porting the React dependency pin to version 17 from the current website hosted at www.worldcommunitygrid.org to the full-featured production website which was also affected. We then need to ensure functionality on all major browsers manually. Once finished, the website and forums will be good to go.

Finally, we were able to test BOINC client connections to our servers from newly created/registered accounts. While we were able to contact the BOINC scheduler and check for available workunits, we are now diagnosing a failure to validate the project key that occured in some cases.

On the server side, we were able to verify the flow of data from our research partners into the workunit management layer in our stack. Thus, this part is fully validated, and will proceed smoothly upon restart. We continue to assess readiness of the workunit management stack for launch together with the website.

Van Facebook (staat nog niet op de site).

Ik hoop dat WCG vóór de zomer nog online komt. Of wellicht trekt Krembil er de stekker wel permanent uit, want erg willig om dit project te draaien lijkt men niet te zijn met hun inmiddels 3 maanden downtime....

[Suicyder]

Ik begin het vertrouwen in die organisatie wel een beetje te verliezen.

Merk ook dat ik steeds minder aandacht er aan besteed. Ofwel minder vaak denk, laat ik eens even kijken of WCG alweer updates heeft.

[wildhagen]

Ja, heb zelf ook ernstig het gevoel dat het wel eens een aflopende zaak kan zijn, nu ze ons zolang aan het lijntje proberen te houden.

[HenkM2]

Sorry, verkeerd draadje.

[Voor 91% gewijzigd door HenkM2 op 13-05-2022 22:52]

[AtHomer]

QA testing has finally successfully finished and all the bugs have been resolved. Production environment is being tested right now.

Considering the unexpected issues we ran into, we prefer to test it a couple of days more.

We will provide further details in the next few days.

Bron: https://twitter.com/WCGrid/status/1528478168151166976

[wildhagen]

Ja, het is goed met ze. Ik begin er klaar mee te raken met die lui.

[Tao]

wildhagen schreef op maandag 23 mei 2022 @ 15:21:
Ja, het is goed met ze. Ik begin er klaar mee te raken met die lui.

Same here

[AtHomer]

Helaas zijn er nog problemen met de productie-omgeving:

We were unable to bring our production environment to the same state as the QA environment this week. As we also have yet to resolve an issue that prevents BOINC clients from downloading workunits, the effort to bring the Grid back online has stretched into next week.

Bron: https://twitter.com/WCGrid/status/1530641121231228928

[wildhagen]

Goh, wat een verassing zeg. Weer uitstel. En volgende week lopen ze weer tegen "problemen" aan. En de week erop weer.

Jongens, geef het gewoon even aan dat je niet geinteresseerd bent in het draaien van het WCG-project. Het ligt er inmiddels wel duidelijk genoeg bovenop.

Ik zie dit voor augustus of september echt niet meer live gaan met alle "problemen" die tegenkomen.

Wat ze dan in de geplande testperiode hebben gedaan, geen idee, want ze komen het allemaal nu pas tegen.

[Tao]

1 ding is zeker: in een professionele organisatie waren er al lang mensen ontslagen.
Dit (plannings- en/of kennis-)niveau is langzaamaan een beetje belachelijk te noemen.

Maar goed: their loss.

[wildhagen]

Van hun bericht van eergisteren:

We will provide a further update on Monday, May 30th.

We zijn nu op de 31e (ook in Canada) en, uiteraard, nog geen update. Zoveelste keer dat ze hun beloften niet nakomen.....

[Voor 3% gewijzigd door wildhagen op 31-05-2022 13:32]

[m_p_g]

WCG June 3rd Update

We are currently working on fixing bugs in our website and experimenting with improved ways to deliver updates to our community.

Published on: 3 June 2022

Dear Volunteers, we have been working hard to enable the restart of the WCG. As anyone who has experienced this journey with us knows, it has been a long and rocky road. Unfortunately, our testing uncovered unforeseen bugs and prevented us from discussing much of our day-to-day work with you. In this update, we wish to give some insight into some of the technical difficulties and new methods of communication we have been working on.

Het is te hopen dat de bugs nu eindelijk een beetje platgeslagen zijn. Dat de website nog bugs bevat en de social media (o.a. email, instagram) nog niet helemaal "up en running" zijn, zou mijns inziens geen showstopper mogen zijn voor het distributie werk van de servers.

De volledige update info is te lezen op de WCG website.
https://secure.worldcommunitygrid.org/news/0603

[wildhagen]

Typerend dat ze kennelijk alleen met de website bezig zijn, maar er met geen enkel woord gerept wordt over het daadwerkelijk wetenschappelijke deel, dus het crunchen.

Ik krijg steeds meer het idee dat het ze geen klap meer boeit, en WCG gewoon stilletjes af laten sterven.

En als het al herstart wordt zie ik, gezien het vele uitstel, dit jaar niet meer gebeuren.

[DaMoUsYs]

Er is weer een update

https://www.worldcommunit...s/article.s?articleId=771

[Tao]

Woow, wat mooi: website en forums zijn back up! /sarcasm mode off

Niets over hervatten van projects / WU's etc. Het zal wel aan mij liggen dat ik wat anders verwachtte van een "update"....

[DrDrax]

OPN1 Project Update 24 jun 2022
https://www.worldcommunit...s/article.s?articleId=772

[wildhagen]

Since many of you have been asking for minor updates to stay informed about the current state of WCG, here is what the team has been working on.

Recent efforts to restart have been unsuccessful. You may have noticed in your BOINC client some messages from the scheduler, which was a byproduct of the successful steps in the restart procedure. However, we have been unable to queue workunits packaged for distribution to clients into the primary scheduler node and are working to resolve what is hopefully the final blocking issue to workunit distribution. We have identified as a result of this issue an opportunity to create a more efficient queue to allocate and distribute work among volunteer devices, which we will release in a future update. but it has been taking time to implement.

Zie https://www.worldcommunit...g/viewthread_thread,44131

Zucht.... we zijn bijna 4.5 maand verder en nog steeds lopen ze tegen van alles en nog wat aan....

[mklcln]

Zo te zien kunnen we weer starten ik heb opnieuw het project toegevoegd als https://master.worldcommunitygrid.org/

En nu heb ik weer projectjes te draaien. Lets GO!!

[wildhagen]

Good news, everyone!

As of this morning, we are extending the testing phase to the larger volunteer base, so many of you may be receiving workunits to crunch! However, this should not be seen as a full restart, there still may be issues and challenges to solve. Specific details of this testing phase will be shared soon. We would like to ask you to help identify any errors that the system may cause so we can resolve them as soon as possible.

Zie https://www.worldcommunit...g/viewthread_thread,44139



Mijn 3 machines krijgen helaas nog geen WU's....

Edit: aanvulling verderop:

This is not a full restart, more like an extensive testing phase. A limited amount of workunits were sent out so some volunteers will not receive them. We will have more news to share regarding the full restart soon. Sorry for the confusion.

[Voor 17% gewijzigd door wildhagen op 06-07-2022 17:45]

[DaMoUsYs]

Ik krijg ook steeds deze melding in de logs

code:

World Community Grid | This project seems to have changed its URL.  When convenient, remove the project, then add https://master.worldcommunitygrid.org/

Al geprobeerd om hem opnieuw toe te voegen maar werkt niet helaas

[m_p_g]

Hi everyone, we've seen some questions repeated among multiple volunteers that we'd like to address quickly.

For volunteers that did not receive any new workunits to crunch, we'd like to emphasize that only a limited amount of workunits were sent out as part of a testing phase. For those of you who were confused by our previous messaging, we're sorry.

About the URL change, please disregard this notice and do not update the URL, as the existing URL is correct.

Wijzig dus niet de URL van WCG !

Na maanden werk zijn blijkbaar nog steeds niet alle zichtbare bugs geplet.

[wildhagen]

m_p_g schreef op vrijdag 8 juli 2022 @ 08:15:
[...]

Na maanden werk zijn blijkbaar nog steeds niet alle zichtbare bugs geplet.

Een heleboel bugs zijn er nog. Wijzigingen die in je Device Profiles worden doorgevoerd op de websites komen bijvoorbeeld niet door in de BOINC-client. Dat is toch een heel serieus probleem.

Sommigen schijnen ingeleverde resultaten helemaal niet meer terug te zien op de website. Dus niet Pending Validation, maar gewoon de hele taak niet meer zichtbaar...

Schijnen ook nog statistiek-problemen op de website te zijn.

Regelmatig ook nog BOINC clients die "Out of disk space' zeggen terwijl er nog plenty ruimte is.

Denk dat het nog wel enkele maanden zal duren voor dit allemaal is gefixed.

[Tao]

Ik wacht het nog maar "even" af. Nog teveel bugs naar mijn smaak.
Wil best opnieuw starten, maar dan onafgebroken genoeg werk krijgen.
En nee, zonder bugs geserveerd te krijgen.

[wildhagen]

Nou, ik heb *eindelijk* mijn eerste WU'tjes binnen hoor...





Zou allemaal wel wat sneller mogen, maar ok...

[Voor 24% gewijzigd door wildhagen op 12-07-2022 17:53]

[wildhagen]

Dear volunteers,

Over the past week, we entered a new stage of our testing phase where we gave a few workunits to our volunteers to crunch. The goal was to see if any unforeseen errors occurred, which we were able to find thanks to the feedback of our volunteers. For specific questions you may have on the limited workunits, check this thread on our forums.

Here’s a quick update from our tech team:

We have been working to assess how well the system responds to load and whether configuration is correct. As many have noted on the forums, there are some issues with the BOINC backend configuration. Users will have noticed off-putting notices in the BOINC manager about incorrect project URLs and attaching twice to the same project. We have addressed the underlying issue and apologize for the inconvenience.

In addition, we are working to resolve the lack of synchronization between the website profile page and the BOINC manager. We are also working to fix a blocking issue with the GPU workunits for Open Pandemics. Once this is resolved, we should be able to increase the quantity of workunits we can send out to volunteers.

Our backlog of non-blocking issues has continued to grow as we observe load on the system, but overall we are nearing a stable state of affairs and look forward to updating users with statistics and more details as we continue the roll out of our production system.

Thank you for your understanding and continued support.

Sincerely,

The World Community Grid team

Zie https://www.worldcommunit...s/article.s?articleId=773

[grass460]

Na een week vakantie krijg ik nu ook wat WU binnen. Niet veel.
Gisteren een hele rits Open Pandemics

Nu ARP project

[Tao]

grass460 schreef op zaterdag 16 juli 2022 @ 09:20:
Na een week vakantie krijg ik nu ook wat WU binnen. Niet veel.
Gisteren een hele rits Open Pandemics

Nu ARP project[Afbeelding]

Ik heb al langer dan een jaar ARP als project aan laten staan. Nooit een WU ontvangen...
Misschien gaat het er ooit eens van komen.

[wildhagen]

Nou, volgens mij is WCG nu echt over en uit. Ik kan het hele domain name niet eens meer resolven.... kennelijk opgeheven ofzo?

[Suicyder]

Heel bijzonder inderdaad, er waren laatste week juist wat admins aan het reageren op het forum op vragen welke gesteld werden en (HEEL IETS) meer info aan het geven geweest.

Ik zie later dit jaar wel op mijn machine nog weer terug kan naar WCG of niet, sowieso met dat warme weer niet alhier.

Echter veel vertrouwen blijft er niet over, met alle zaken bij elkaar.

[Voor 11% gewijzigd door Suicyder op 26-07-2022 07:54]

[Suicyder]

Nou de website is weer online, kennelijk hebben ze netwerk issues gehad. Maar verder geen extra info.

[Suicyder]

Research update from the SCC team

[wildhagen]

Interview with Africa Rainfall Project team